Open Access<p>Current Perspectives on Diagnostic Assays and Anti-PF4 Antibodies for the Diagnosis of Heparin-Induced Thrombocytopenia</p>
Author(s) -
Kamal Kant Sahu,
Vishal Jindal,
J. Anderson,
Ahmad Daniyal Siddiqui,
Ishmael Jaiyesimi
Publication year - 2020
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s232648
Subject(s) - medicine , heparin induced thrombocytopenia , heparin , turnaround time , intensive care medicine , platelet factor 4 , clinical practice , physical therapy , computer science , operating system
Heparin-induced thrombocytopenia (HIT) is a recognized clinical entity in patients receiving unfractionated heparin and low-molecular weight heparin. Currently, diagnosing HIT includes the combination of a physician's clinical suspicion based on a clinical scoring system and a series of laboratory tests. In the present article, we discuss challenges in suspecting and diagnosing HIT in consideration of the turnaround time of available tests and recent advances in techniques and methodologies of newer immunoassays and functional assays.