Open Access<p>Serum Expression of Seven MicroRNAs in Chronic Lymphocytic Leukemia Patients</p>
Author(s) -
Ehsan Farzadfard,
Tahereh Kalantari,
Gholamhossein Tamaddon
Publication year - 2020
Publication title -
journal of blood medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.676
H-Index - 18
ISSN - 1179-2736
DOI - 10.2147/jbm.s230842
Subject(s) - microrna , chronic lymphocytic leukemia , medicine , leukemia , cancer , trizol , real time polymerase chain reaction , flow cytometry , oncology , pathogenesis , rna , immunology , gene , biology , rna extraction , genetics
MicroRNAs are small single-strand noncoding RNAs that can be deregulated in a variety of cancers. Over the past few years, multiple markers have been discovered in chronic lymphocytic leukemia (CLL). Among these, miRNAs seem to have important roles in the pathogenesis of CLL. The development and validation of miRNA-expression patterns as biomarkers should have a significant impact in cancer diagnosis, therapeutic success, and increasing the life expectancy of patients. In this study, to specify the utility of circulatory miRNA expression as noninvasive and useful biomarkers for CLL, we analyzed the dysregulation of seven miRNAs: miR30d, miR25-3p, miR19a-3p, miR133b, miR451a, miR145, and miR144 in CLL-patient sera.