Open AccessMALAT1 Induces Food Allergy by Promoting Release of IL-6 from Dendritic Cells and Suppressing the Immunomodulatory Function of Tregs
Author(s) -
Hao Feng,
Xiujuan Xiong,
Zhuo Chen,
Nan Luo,
Yongning Wu
Publication year - 2022
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s341742
Subject(s) - ovalbumin , medicine , dendritic cell , immunology , malat1 , immune system , inflammation , eosinophil , biology , downregulation and upregulation , biochemistry , long non coding rna , asthma , gene
Dendritic cells (DCs) comprise a valuable target for immune-modulation in food allergy (FA). Long noncoding RNA (lncRNA), metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has immunomodulatory capacities and may influence the outcome of DC antigen presentation. However, the precise molecular mechanisms underlying the implication of MALAT1 in FA remain unclear.