Open AccessPTPRH Alleviates Airway Obstruction and Th2 Inflammation in Asthma as a Protective Factor
Author(s) -
F Chen,
Du Li,
Zhimin Zeng,
Xiaoqi Huang,
Xu Chen,
WenSong Tan,
Changsheng Xie,
Yucheng Liang,
Yang Guo
Publication year - 2022
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s340059
Subject(s) - medicine , asthma , protein kinase b , airway obstruction , inflammation , phosphorylation , mucus , immunology , transfection , airway , house dust mite , allergy , cell culture , allergen , biology , anesthesia , microbiology and biotechnology , ecology , genetics
PTPRH inhibits EGFR activity directly in cancer patients and activated EGFR induces goblet cell hyperplasia and mucus hypersecretion in asthma. However, the function of PTPRH in asthma remains unknown. The purpose of this study was to access the association of PTPRH with asthma and its underlying mechanism.