Open AccessPersistent Eosinophilic Inflammation in Adult Asthmatics with High Serum and Urine Levels of Leukotriene E4
Author(s) -
Ga Young Ban,
Seung Hyun Kim,
HaeSim Park
Publication year - 2021
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s325499
Subject(s) - medicine , asthma , leukotriene e4 , eosinophil , eosinophilia , leukotriene , bronchoconstriction , leukotriene receptor , aspirin , urine , immunology , arachidonic acid , gastroenterology , biochemistry , chemistry , enzyme
Cysteinyl leukotrienes (CysLTs) are key mediators for bronchoconstriction, eosinophil recruitment and mucus production in the airways of asthmatic patients. To better understand the role of CysLTs in different asthma phenotypes, we compared the levels of arachidonic acid metabolites in relation to asthma control status and phenotypes in adult asthmatics on regular anti-asthma medications.