Open AccessCyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response
Author(s) -
Cai-Tao Chen,
Chunxiao Shan,
Jun Ran,
LeiMiao Yin,
Haiyan Li,
Yu Wang,
YouPing Xu,
Jun Guo,
Yang-Lin Shi,
Yanjiao Chen,
Yongqing Yang
Publication year - 2021
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s308938
Subject(s) - medicine , cyclophilin a , immunology , ex vivo , ovalbumin , immunoglobulin e , interleukin 4 , in vivo , immune system , cytokine , endocrinology , microbiology and biotechnology , biology , antibody
Cyclophilin A (CypA) inhibits CD4 + T cell signal transduction via interleukin-2-inducible T-cell kinase (Itk), a tyrosine kinase required for T helper (Th) 2 cells function. Furthermore, mice with CypA silencing developed allergic diseases associated with increased Th2 cytokines production. CD4 + T cells with a Th2-cytokine pattern have been demonstrated to have a pivotal role in the pathogenesis of asthma. However, the effects of CypA in regulating immunity in asthma and in relieving asthmatic symptoms in vivo are entirely unknown.