Open AccessMiR-21-5p in Macrophage-Derived Exosomes Targets Smad7 to Promote Epithelial Mesenchymal Transition of Airway Epithelial Cells
Author(s) -
Xiang Li,
Nan Yang,
Qi Cheng,
Han Zhang,
Fen Liu,
Yunxiao Shang
Publication year - 2021
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s307165
Subject(s) - exosome , microvesicles , epithelial–mesenchymal transition , microbiology and biotechnology , stromal cell , respiratory epithelium , smad , mesenchymal stem cell , medicine , macrophage , downregulation and upregulation , immunology , cancer research , epithelium , signal transduction , microrna , pathology , biology , in vitro , biochemistry , gene
Asthma is usually associated with airway inflammation and airway remodeling. Epithelial mesenchymal transition (EMT) often occurs in airway remodeling. The purpose of this study is to identify the effect of miR-21-5p and Smad7 signaling pathway in macrophage-derived exosomes on EMT of airway epithelial cells.