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Patients with variable symptoms suggestive of asthma but with normal forced expiratory volume in 1 second (FEV 1 ) often fail to be diagnosed without a bronchial provocation test, but the test is expensive, time-consuming, risky, and not readily available in all clinical settings.

journal of asthma and allergy

Small-Airway Function Variables in Spirometry, Fractional Exhaled Nitric Oxide, and Circulating Eosinophils Predicted Airway Hyperresponsiveness in Patients with Mild Asthma