Open AccessSLAMs Negatively Regulate IL-21 Production in Tfh-Like Cells from Allergic Rhinitis Patients
Author(s) -
Jun Yang,
Long Geng,
Yihui Ma,
Xinyi Tang,
Huiyong Peng,
Jie Tian,
Huaxi Xu,
Shengjun Wang
Publication year - 2021
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s291879
Subject(s) - cxcr5 , flow cytometry , immunoglobulin e , immunology , pathogenesis , antibody , in vitro , medicine , b cell , biology , germinal center , biochemistry
Allergic rhinitis (AR) is characterized by type I hypersensitivity that is mediated by IgE-induced humoral responses. Follicular helper T cells (Tfh) comprise the key helper T cell (Th) subset that promotes antibody production. Signaling lymphocytic activation molecules (SLAMs) participate in regulation of the differentiation and function of Tfh cells, but whether this regulation is involved in the pathogenesis of AR is unknown.