Open AccessLncRNA H19 Inhibits Proliferation and Migration of Airway Smooth Muscle Cells Induced by PDGF-BB Through miR-21/PTEN/Akt Axis
Author(s) -
Huansha Yu,
Ningning Qi,
Quan Zhou
Publication year - 2021
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s291333
Subject(s) - pten , protein kinase b , phosphorylation , cell growth , transfection , platelet derived growth factor receptor , medicine , cancer research , microbiology and biotechnology , signal transduction , biology , growth factor , pi3k/akt/mtor pathway , cell culture , receptor , biochemistry , genetics
LncRNA H19 expression is down-regulated in patients with asthma. The hyperplasia of airway smooth muscle cells (ASMCs) promotes the development of airway remodeling in asthma. Therefore, we attempted to evaluate the regulatory function of H19 in the proliferation and migration of ASMCs.