Open AccessIn vitro Culture with Cytokines Provides a Tool to Assess the Effector Functions of ILC2s in Peripheral Blood in Asthma
Author(s) -
Li Y. Drake,
Kathleen R. Bartemes,
Kay Bachman,
John B. Hagan,
Hirohito Kita
Publication year - 2021
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s286695
Subject(s) - peripheral blood mononuclear cell , medicine , innate lymphoid cell , immunology , flow cytometry , cytokine , asthma , in vitro , immune system , immunity , biology , biochemistry
Group 2 innate lymphoid cells (ILC2s) play crucial roles in type 2 immunity and asthma development. While ILC2s are resident in mucosal tissues, they also circulate in peripheral blood. It remains controversial whether ILC2s are increased in the peripheral blood of patients with asthma.