Open Access<p>Action of 1,25(OH)<sub>2</sub>D<sub>3</sub> on Human Asthmatic Bronchial Fibroblasts: Implications for Airway Remodeling in Asthma</p>
Author(s) -
Maria Plesa,
Mellissa Gaudet,
Andrea Mogas,
Ronald Olivenstein,
Saba Al Heialy,
Qutayba Hamid
Publication year - 2020
Publication title -
journal of asthma and allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.162
H-Index - 30
ISSN - 1178-6965
DOI - 10.2147/jaa.s261271
Subject(s) - tumor necrosis factor alpha , calcitriol receptor , medicine , transforming growth factor , fibrosis , vitamin d and neurology , fibroblast , endocrinology , cancer research , immunology , biology , in vitro , biochemistry
Airway fibroblasts are major contributors to the histopathological feature of airway remodeling in asthma by their implication in the cell invasiveness and profibrogenic secretory phenotype observed in subepithelial fibrosis. 1,25 Dihydroxy vitamin D 3 (1,25(OH) 2 D 3 ) is an important therapeutic agent that blocks many features of airway remodeling induced by profibrogenic mediators, such as transforming growth factor beta 1 (TGF-β1) or T helper type 1 inflammatory cytokines.