Open AccessPriming Leukemia with 5-Azacytidine Enhances CAR T Cell Therapy
Author(s) -
Nuo Xu,
Benjamin Tse,
Lu Yang,
Tiffany C. Y. Tang,
Michelle Haber,
Kenneth Micklethwaite,
Alla Dolnikov
Publication year - 2021
Publication title -
immunotargets and therapy
Language(s) - English
Resource type - Journals
ISSN - 2253-1556
DOI - 10.2147/itt.s296161
Subject(s) - leukemia , priming (agriculture) , t cell , cancer research , biology , cd19 , chimeric antigen receptor , cell , immunology , microbiology and biotechnology , chemistry , immune system , biochemistry , botany , germination
Despite the success of chimeric antigen receptor (CAR) T cells in clinical studies, a significant proportion of responding patients eventually relapsed, with the latter correlating with low CAR T cell expansion and persistence.