Open AccessDupilumab Induced Limbal Stem Cell Deficiency
Author(s) -
Urmi Mehta,
Marjan Farid
Publication year - 2021
Publication title -
international medical case reports journal
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 11
ISSN - 1179-142X
DOI - 10.2147/imcrj.s308583
Subject(s) - dupilumab , medicine , stem cell , ophthalmology , dermatology , atopic dermatitis , biology , microbiology and biotechnology
Dupilumab is a monoclonal antibody that is used for the treatment of atopic dermatitis (AD) in adults. However, increasing reports of ocular complications including conjunctivitis and dry eye disease have been documented. In this report, we describe a case of a patient who developed limbal stem cell deficiency (LSCD) after prolonged Dupilumab use. A 56-year-old Caucasian male with a history of AD presented with gradual onset cloudy vision and extensive diffuse symblepharon resulting from Dupilumab treatment. He was diagnosed with cicatrizing blepharoconjunctivitis and secondary LSCD after slit lamp examination. In conclusion, LSCD secondary to cicatricial disease is a severe adverse ocular complication caused from long-term Dupilumab treatment.