Open AccessThe Optimal Haemoglobin Target in Dialysis Patients May Be Determined by Its Contrasting Effects on Arterial Stiffness and Pressure Pulsatility
Author(s) -
Hon-Chun Hsu,
Chanel Robinson,
Gavin R. Norton,
Angela J. Woodiwiss,
Patrick H Dessein
Publication year - 2020
Publication title -
international journal of nephrology and renovascular disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.846
H-Index - 27
ISSN - 1178-7058
DOI - 10.2147/ijnrd.s285168
Subject(s) - arterial stiffness , medicine , pulse wave velocity , cardiology , pulse pressure , blood pressure , mean arterial pressure , aortic pressure , diabetes mellitus , endocrinology , heart rate
It remains unclear why the optimal haemoglobin target is lower in patients with chronic kidney disease (CKD) than in non-CKD persons. Arteriosclerosis and consequent impaired arterial function comprise a central cardiovascular risk mechanism in CKD. We hypothesized that the optimal haemoglobin target depends on its opposing effects on arterial stiffness and pressure pulsatility in CKD.