Open AccessTumor Microenvironment Multiple Responsive Nanoparticles for Targeted Delivery of Doxorubicin and CpG Against Triple-Negative Breast Cancer
Author(s) -
Fenfen Gu,
Chuling Hu,
Wei Cao,
Chao Li,
Qingming Xia,
Yuan Gao,
Yan Liu,
Shen Gao
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s377702
Subject(s) - triple negative breast cancer , doxorubicin , cancer research , tumor microenvironment , cancer , breast cancer , triple negative , medicine , nanotechnology , materials science , chemotherapy , tumor cells
Currently, the main treatment for advanced breast cancer is still chemotherapy. Immunological and chemical combination therapy has a coordinated therapeutic effect and achieves some efficacy. However, the immunosuppressive tumor microenvironment is a major cause for the failure of immunotherapy in breast cancer. CpG oligodeoxynucleotides can activate the tumor immune microenvironment to reverse the failure of immunotherapy.