Open AccessDrug-Loaded Acoustic Nanodroplet for Dual-Imaging Guided Highly Efficient Chemotherapy Against Nasopharyngeal Carcinoma
Author(s) -
Dayan Yang,
Qiqing Chen,
Min Zhang,
Guiying Feng,
Dawei Sun,
Gang Li,
Xiangxiang Jing
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s377514
Subject(s) - doxorubicin , drug delivery , chemotherapy , distribution (mathematics) , drug , biodistribution , medicine , cancer research , magnetic resonance imaging , biomedical engineering , materials science , pharmacology , chemistry , in vitro , nanotechnology , surgery , radiology , mathematical analysis , biochemistry , mathematics
Chemotherapy is an important approach to treating nasopharyngeal carcinoma (NPC). Unfortunately, the lack of selectivity, insufficient tumor accumulation, uneven tumor distribution and severe systemic toxicity lead to the unsatisfactory performance of these drugs. While a more precise drug delivery, on-demand drug release, and deep diffusion of drugs (homogeneous distribution of drugs in the tumor) could improve the application, they remain challenging. Chemotherapeutic drug-loaded acoustic nanodroplet with dual-imaging capacity is expected to solve these problems.