Open AccessDevelopment of Injectable and Biodegradable Needle-Type Starch Implant for Effective Intratumoral Drug Delivery and Distribution
Author(s) -
Changkyu Lee
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s370194
Subject(s) - biodistribution , in vivo , drug delivery , implant , pharmacology , ex vivo , drug , cytotoxicity , biomedical engineering , distribution (mathematics) , self healing hydrogels , drug carrier , controlled release , medicine , materials science , in vitro , chemistry , surgery , nanotechnology , biology , biochemistry , mathematical analysis , microbiology and biotechnology , mathematics , polymer chemistry
Compared to intravenous administration, intratumoral drug administration enables the direct delivery of drugs to tumors and mitigates the systemic absorption of drugs and associated drug-induced side effects. However, intratumoral drug administration presents several challenges. The high interstitial fluid pressure (IFP) of the tumor prevents the retention of drugs within the tumor; thus, significant amounts of the drugs are absorbed systemically through the bloodstream or delivered to non-target sites. To solve this problem, in this study, a drug-enclosed needle-type starch implant was developed that can overcome IFP and remain in the tumor.