Open AccessAugmented in vitro and in vivo Profiles of Brimonidine Tartrate Using Gelatinized-Core Liposomes
Author(s) -
Engy A. Abdel Azim,
Seham A. Elkheshen,
Rania M. Hathout,
Marwa A. Fouly,
Nada M. El Hoffy
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s370192
Subject(s) - liposome , in vivo , in vitro , core (optical fiber) , materials science , nanotechnology , chemistry , biophysics , biochemistry , biology , microbiology and biotechnology , composite material
The low entrapment efficiency of the hydrophilic drugs such as brimonidine tartrate (BRT) in liposomes represents a challenge that requires interventions. Gelatinized core liposomes (GCLs) were fabricated to increase the drug entrapment, corneal penetration, and physical stability of the investigated molecule.