Open AccessIonizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes
Author(s) -
Sérgio Scalzo,
Anderson K. Santos,
Heloísa Aparecida Ferreira,
Pedro Augusto Carvalho Costa,
Pedro Henrique Dias Moura Prazeres,
Natália Jordana Alves da Silva,
Lays Cordeiro Guimarães,
Mário de Morais E Silva,
Marco Túllio Rodrigues Alves,
Celso Tarso Rodrigues Viana,
Itamar Couto Guedes de Jesus,
Alice P Rodrigues,
Alexander Birbrair,
Anderson Oliveira Lobo,
Frédéric Frézard,
Michael J. Mitchell,
Sílvia Guatimosim,
Pedro Pires Goulart Guimarães
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s366962
Subject(s) - gene delivery , transfection , genetic enhancement , in vivo , in vitro , viral vector , vector (molecular biology) , microbiology and biotechnology , chemistry , cell , gene , biology , biochemistry , recombinant dna
Gene therapy is a promising approach to be applied in cardiac regeneration after myocardial infarction and gene correction for inherited cardiomyopathies. However, cardiomyocytes are crucial cell types that are considered hard-to-transfect. The entrapment of nucleic acids in non-viral vectors, such as lipid nanoparticles (LNPs), is an attractive approach for safe and effective delivery.