Open AccessGlucose Metabolism Intervention-Facilitated Nanomedicine Therapy
Author(s) -
Zhiyan Li,
Xianghui Li,
Shichao Ai,
Song Liu,
Wenxian Guan
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s364840
Subject(s) - nanomedicine , cancer therapy , cancer , glucose oxidase , carbohydrate metabolism , medicine , pharmacology , metabolism , detoxification (alternative medicine) , cancer research , bioinformatics , chemistry , biology , biochemistry , nanotechnology , pathology , materials science , alternative medicine , nanoparticle , biosensor
Ordinarily, cancer cells possess features of abnormally increased nutrient intake and metabolic pathways. The disorder of glucose metabolism is the most important among them. Therefore, starvation therapy targeting glucose metabolism specifically, which results in metabolic disorders, restricted synthesis, and inhibition of tumor growth, has been developed for cancer therapy. However, issues such as inadequate targeting effectiveness and drug tolerance impede their clinical transformation. In recent years, nanomaterial-assisted starvation treatment has made significant progress in addressing these challenges, whether as a monotherapy or in combination with other medications. Herein, representative researches on the construction of nanosystems conducting starvation therapy are introduced. Elaborate designs and interactions between different treatment mechanisms are meticulously mentioned. Not only are traditional treatments based on glucose oxidase involved, but also newly sprung small molecule agents targeting glucose metabolism. The obstacles and potential for advancing these anticancer therapies were also highlighted in this review.