Open AccessOptimization of Lipid Nanoformulations for Effective mRNA Delivery
Author(s) -
Huiling Chen,
Xuan Ren,
Shengyuan Xu,
Dekui Zhang,
Tiyun Han
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s363990
Subject(s) - in vitro , messenger rna , in vivo , transfection , chemistry , pharmacology , medicine , biology , biochemistry , microbiology and biotechnology , gene
Since the coronavirus disease 2019 (COVID-19) pandemic, the value of mRNA vaccine has been widely recognized worldwide. Messenger RNA (mRNA) therapy platform provides a promising alternative to DNA delivery in non-viral gene therapy. Lipid nanoparticles (LNPs), as effective mRNA delivery carriers, have been highly valued by the pharmaceutical industry, and many LNPs have entered clinical trials.