Open AccessA Ternary Synergistic eNOS Gene Delivery System Based on Calcium Ion and L-Arginine for Accelerating Angiogenesis by Maximizing NO Production
Author(s) -
Guiming Zhang,
Shangcong Han,
Lisheng Wang,
Yang Yu,
Kai Chen,
Si Chen
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s363168
Subject(s) - enos , angiogenesis , nitric oxide , in vivo , transfection , calcium , arginine , gene delivery , chemistry , inflammation , therapeutic angiogenesis , pharmacology , biochemistry , nitric oxide synthase , microbiology and biotechnology , biology , immunology , neovascularization , cancer research , gene , organic chemistry , amino acid
This study aimed to construct a delivery system based on L-arginine-modified calcium phosphate (CaP) to load eNOS plasmids (peNOS), which could amply nitric oxide (NO) to repair endothelial damage, promote angiogenic activities and alleviate inflammation.