Open AccessAn Acid-Sensitive Nanofiber Conjugate Based on a Short Aromatic Peptide for Targeted Delivery of Doxorubicin in Liver Cancer
Author(s) -
Liang Ju,
Runfa Guo,
Maosong Xuan,
Qiankun Sun,
Wen-Lan Wu
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s359642
Subject(s) - doxorubicin , conjugate , nanofiber , peptide , liver cancer , cancer , cancer research , nanotechnology , materials science , chemistry , medicine , biochemistry , chemotherapy , mathematical analysis , mathematics
This study aimed to construct a DOX conjugate with liver tumor targeting and acid sensitivity based on a short aromatic peptide FFYEE, which could amplify the tumor inhibition efficacy of DOX and alleviate tissue toxicity.