Open AccessGentiopicroside PLGA Nanospheres: Fabrication, in vitro Characterization, Antimicrobial Action, and in vivo Effect for Enhancing Wound Healing in Diabetic Rats
Author(s) -
May Almukainzi,
Thanaa A. ElMasry,
Walaa A. Negm,
Engy Elekhnawy,
Asmaa Saleh,
Ahmed E Sayed,
Mohamed Khattab,
Dalia H. Abdelkader
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s358606
Subject(s) - in vivo , wound healing , antimicrobial , in vitro , plga , biomedical engineering , materials science , pharmacology , nanotechnology , medicine , chemistry , microbiology and biotechnology , surgery , biochemistry , biology
Gentiopicroside (GPS), an adequate bioactive candidate, has a promising approach for enhancing wound healing due to its antioxidant and antimicrobial properties. Its poor aqueous solubility negatively affects oral absorption accompanied by low bioavailability due to intestinal/hepatic first-pass metabolism. Our aim in this study is to fabricate GPS into appropriate nanocarriers (PLGA nanospheres, NSs) to enhance its solubility and hence its oral absorption would be improved.