Open AccessNanomedicine: An Emerging Novel Therapeutic Strategy for Hemorrhagic Stroke
Author(s) -
Yating Xu,
Anqi Chen,
Jiehong Wu,
Yan Wan,
Mingfeng You,
Xinmei Gu,
Hongxiu Guo,
Sengwei Tan,
Quanwei He,
Bo Hu
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s357598
Subject(s) - nanomedicine , stroke (engine) , medicine , neuroprotection , intracerebral hemorrhage , drug delivery , regeneration (biology) , hemostasis , pharmacology , intensive care medicine , nanotechnology , materials science , subarachnoid hemorrhage , surgery , nanoparticle , mechanical engineering , microbiology and biotechnology , engineering , biology
Hemorrhagic stroke is one of the most devastating diseases worldwide due to a high rate of disability and mortality with few effective treatments. Recent advances in nanomedicines to promote hemostasis, drug delivery, neuroprotection, and nerve regeneration may provide insight into hemorrhagic stroke treatment. In this review, we first view the pathophysiology and conventional therapeutics of hemorrhagic stroke. Second, we comprehensively summarize the current nanomedicines applied in hemorrhagic stroke, including inorganic nanomaterials, polymer-based nanomaterials, lipid-based nanomaterials, self-assembling peptide-based hydrogel, exosomes, and gel systems. Finally, the challenges, opportunities, and future perspectives of nanomedicines for hemorrhagic stroke are discussed. Thus, this review promotes greater exploration of effective therapies for hemorrhagic stroke with nanomedicines.