Open AccessBiomimetic Mineralized Hydroxyapatite Nanofiber-Incorporated Methacrylated Gelatin Hydrogel with Improved Mechanical and Osteoinductive Performances for Bone Regeneration
Author(s) -
He Wang,
Bo Hu,
Hong Li,
Feng Gao,
Shengyuan Pan,
Ziqi Chen,
Bo Li,
Jinlin Song
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s354127
Subject(s) - materials science , biocompatibility , self healing hydrogels , gelatin , biomedical engineering , apatite , simulated body fluid , swelling , tissue engineering , composite number , bone tissue , bone healing , regeneration (biology) , nanofiber , biomaterial , artificial bone , composite material , chemistry , nanotechnology , surgery , polymer chemistry , scanning electron microscope , mineralogy , medicine , biochemistry , metallurgy , biology , microbiology and biotechnology
Methacrylic anhydride-modified gelatin (GelMA) hydrogels exhibit many beneficial biological features and are widely studied for bone tissue regeneration. However, deficiencies in the mechanical strength, osteogenic factors and mineral ions limit their application in bone defect regeneration. Incorporation of inorganic fillers into GelMA to improve its mechanical properties and bone regenerative ability has been one of the research hotspots.