Open AccessTriazine–Carbosilane Dendrimersomes Enhance Cellular Uptake and Phototoxic Activity of Rose Bengal in Basal Cell Skin Carcinoma Cells
Author(s) -
Krzysztof Sztandera,
Michał Gorzkiewicz,
Mateusz Bątal,
Valeria Arkhipova,
Nadezhda Knauer,
Javier SánchezNieves,
F. Javier de la Mata,
Rafael Gómez,
Evgeny Apartsin,
Barbara KlajnertMaculewicz
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s352349
Subject(s) - phototoxicity , photosensitizer , rose bengal , photodynamic therapy , confocal microscopy , biophysics , viability assay , flow cytometry , chemistry , drug delivery , in vitro , nanotechnology , materials science , biochemistry , microbiology and biotechnology , biology , organic chemistry
The search for new formulations for photodynamic therapy is intended to improve the outcome of skin cancer treatment using significantly reduced doses of photosensitizer, thereby avoiding side effects. The incorporation of photosensitizers into nanoassemblies is a versatile way to increase the efficiency and specificity of drug delivery into target cells. Herein, we report the loading of rose bengal into vesicle-like constructs of amphiphilic triazine-carbosilane dendrons (dendrimersomes) as well as biophysical and in vitro characterization of this novel nanosystem.