Open AccessCefquinome Sulfate Oily Nanosuspension Designed for Improving its Bioavailability in the Treatment of Veterinary Infections
Author(s) -
Yujuan Mao,
Yumeng Chen,
Chang Liu,
Xingyue He,
Yi Zheng,
Xiaolan Chen,
Ying Wang,
Wei Chen,
Yue Wu,
Yan Shen,
Haifeng Yang,
Songbo Ma
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s348822
Subject(s) - bioavailability , medicine , sulfate , pharmacology , chemistry , organic chemistry
Cefquinome sulfate (CS) is the first fourth-generation antibiotic for animals, which has a wide antibacterial spectrum, strong antibacterial activity and low drug resistance. However, it is accompanied by problems of poor therapeutic efficacy. In this context, the use of nanosuspensions have been found to be an attractive strategy. The main objective of this work is to develop a new oily nanosuspension to improve bioavailability and stability of CS formulations.