Open AccessPseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway
Author(s) -
Yang Fu,
Peipei Yuan,
Yajuan Zheng,
Yaxin Wei,
Liyuan Gao,
Yuan Ruan,
Yi Chen,
Pan-Ying Li,
Weisheng Feng,
Xiaoke Zheng
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s348673
Subject(s) - toxicity , oxidative stress , reproductive toxicity , in vivo , apoptosis , pharmacology , chemistry , gnrhr , sperm , hormone , biology , gonadotropin releasing hormone , medicine , biochemistry , andrology , luteinizing hormone , microbiology and biotechnology , organic chemistry
Pseudoephedrine (PSE) has rapid absorption and metabolism, which limits its pharmacologic actions. We postulated that pseudoephedrine nanoparticles (PSE-NPs) with high bioavailability could overcome this limitation. The defensive function of PSE-NPs nanoparticles against adriamycin-induced reproductive toxicity in mice was studied.