Open AccessPeriodontal Ligament Stem Cell-Derived Small Extracellular Vesicles Embedded in Matrigel Enhance Bone Repair Through the Adenosine Receptor Signaling Pathway
Author(s) -
Biwei Zhao,
Qingqing Chen,
Li-Ru Zhao,
Jiaqi Mao,
Wei Huang,
Xinxin Han,
Yuehua Liu
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s346755
Subject(s) - matrigel , microbiology and biotechnology , protein kinase b , stem cell , extracellular matrix , mesenchymal stem cell , periodontal ligament stem cells , cell migration , chemistry , materials science , biology , signal transduction , cell , alkaline phosphatase , biochemistry , enzyme
Small extracellular vesicles (sEVs) are natural biocarriers for biomolecule transfer between cells and promising therapeutic strategies for bone defect repair. In this study, human periodontal ligament stem cell (PDLSC)-derived sEVs (P-EVs) were immobilized in Matrigel to establish a topical cell-free transplantation strategy for bone repair.