Open AccessHybrid Cell Membrane-Functionalized Biomimetic Nanoparticles for Targeted Therapy of Osteosarcoma
Author(s) -
Jiaxin Cai,
Jihua Liu,
Junyong Wu,
Yong-Jiang Li,
Xiaohan Qiu,
Wenjie Xu,
Ping Xu,
DaXiong Xiang
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s346685
Subject(s) - plga , zeta potential , materials science , flow cytometry , drug delivery , in vivo , osteosarcoma , cancer research , medicine , nanoparticle , nanotechnology , immunology , biology , microbiology and biotechnology
In order to prepare a biomimetic nano-carrier which has inflammatory chemotaxis, homologous targeting and reduce immune clearance, for targeted chemotherapy of osteosarcoma, we fabricated the paclitaxel-loaded poly(lactic-co-glycolic) acid (PLGA) nanoparticles coated with 143B-RAW hybrid membrane (PTX-PLGA@[143B-RAW] NPs) and evaluate its anti-cancer efficacy in vitro and vivo.