Open AccessHighly Sensitive Lanthanide-Doped Nanoparticles-Based Point-of-Care Diagnosis of Human Cardiac Troponin I
Author(s) -
Lu Chen,
Shanyong Zhou,
Wenwu Zhu,
Sheng-Ping Liu,
Jingxi Zhang,
Zuyuan He,
Jingling Zhang,
Yongsheng Li,
Fei Gao
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s346415
Subject(s) - troponin i , lanthanide , detection limit , point of care testing , materials science , point of care , nanoparticle , nanotechnology , biomedical engineering , doping , myocardial infarction , medicine , chromatography , chemistry , optoelectronics , pathology , ion , organic chemistry
Cardiac troponin I (cTnI) has been regarded as a gold standard for early diagnosis and prognosis monitoring of acute myocardial infarction (AMI) in clinical practice. Owing to its low concentration in blood, accurate determination of cTnI often requires high sensitivity. However, current established point-of-care (POC) assays are insufficient to meet clinically analytical requirements due to their low sensitivity.