Open AccessA Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma
Author(s) -
Lei Dong,
Nana Li,
Xixi Wei,
Yongling Wang,
Liansheng Chang,
Hongwei Wu,
Liujiang Song,
Kang Guo,
Yung-Fu Chang,
Yulong Yin,
Min Pan,
Yuanyuan Shen,
Rui Wang
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s344940
Subject(s) - plga , gambogic acid , glioma , microbubbles , drug delivery , u87 , cancer research , glioblastoma , blood–brain barrier , materials science , pharmacology , biomedical engineering , chemistry , nanoparticle , medicine , ultrasound , nanotechnology , central nervous system , in vitro , biochemistry , radiology
The blood-brain barrier (BBB) inhibits the delivery of macromolecular chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects to surrounding tissues and organs. Ultrasonic targeted microbubble destruction (UTMD) technology can open the BBB, leading to a new type of drug delivery system with particular utility in glioma.