Open AccessAssessment to the Antifungal Effects in vitro and the Ocular Pharmacokinetics of Solid-Lipid Nanoparticle in Rabbits
Author(s) -
Zhen Liang,
Zhen Zhang,
Jingjing Yang,
Ping Lü,
Tianyang Zhou,
Jingguo Li,
Junjie Zhang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s340068
Subject(s) - solid lipid nanoparticle , bioavailability , pharmacology , pharmacokinetics , in vivo , fungal keratitis , drug , cornea , chemistry , keratitis , medicine , dermatology , ophthalmology , biology , microbiology and biotechnology
Fungal keratitis (FK) remains a severe sight-threatening disease, and case management is difficult due to ocular intrinsic barriers and drug shortages. Econazole (ECZ), a broad-spectrum antifungal agent, is limited in ocular applications due to the poor water solubility and strong irritant property.