Open AccessPeripheral Serum Exosomes Isolated from Patients with Acute Myocardial Infarction Promote Endothelial Cell Angiogenesis via the miR-126-3p/TSC1/mTORC1/HIF-1α Pathway
Author(s) -
Shasha Duan,
Chao Wang,
Xiao Xu,
Xiaoshan Zhang,
Gaofeng Su,
You Li,
Shuai Fu,
Sun Park,
Jiawei Tian
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s338937
Subject(s) - angiogenesis , microvesicles , medicine , cancer research , vascular endothelial growth factor a , immunology , vascular endothelial growth factor , microbiology and biotechnology , biology , microrna , vegf receptors , biochemistry , gene
Angiogenesis is required for improving myocardial function and is a key factor in long-term prognosis after an acute myocardial infarction (AMI). Although exosomes are known to play a crucial role in angiogenesis, the role of peripheral exosomes in angiogenic signal transduction in patients with AMI remains unclear. Here, we explored the effect of exosomes extracted from the peripheral serum of AMI patients on angiogenesis and elucidated the downstream pathways.