Open AccessMultiplexed Molecular Imaging Strategy Integrated with RNA Sequencing in the Assessment of the Therapeutic Effect of Wharton’s Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoporosis
Author(s) -
Cheng-Hsiu Lu,
Yi-An Chen,
Chien-Chih Ke,
Sain-Jhih Chiu,
Fong-Shya Jeng,
Chao-Cheng Chen,
Ya-Ju Hsieh,
Baofeng Yang,
ChiWei Chang,
FengSheng Wang,
Ren-Shyan Liu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s335757
Subject(s) - mesenchymal stem cell , osteoporosis , ovariectomized rat , microrna , protein kinase b , molecular imaging , pi3k/akt/mtor pathway , in vivo , rna , microbiology and biotechnology , microvesicles , downregulation and upregulation , cancer research , chemistry , medicine , biology , signal transduction , pathology , gene , biochemistry , genetics , estrogen
Osteoporosis is a result of an imbalance in bone remodeling. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been considered as a potentially promising treatment for osteoporosis. However, the therapeutic effect, genetic alterations, and in vivo behavior of exogenous EVs for osteoporosis in mice models remain poorly understood.