Open AccessExtracellular Vesicles from HIF-1α-Overexpressing Adipose-Derived Stem Cells Restore Diabetic Wounds Through Accelerated Fibroblast Proliferation and Migration
Author(s) -
Jie Wang,
Hao Wu,
Yue Zhao,
Yong Qin,
Yingbo Zhang,
Haijun Pang,
Yongting Zhou,
Xueyi Liu,
Zhibo Xiao
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s335438
Subject(s) - wound healing , microbiology and biotechnology , extracellular matrix , stem cell , extracellular vesicle , inflammation , pi3k/akt/mtor pathway , biology , cancer research , immunology , signal transduction , microrna , microvesicles , biochemistry , gene
Inhibition of cellular adaptation to hypoxia can cause persistent inflammation, thereby increasing tissue damage and complicating wound healing in diabetes patients. Regulating cellular adaptation to hypoxic environments can help in effective wound repair. Hypoxia-inducible factor (HIF)-1 α is a key regulator of cell hypoxia. Extracellular vesicles (EVs) regulate wound repair. This study investigated the mechanism of HIF-1α overexpression in adipose-derived stem cell extracellular vesicles (ADSCs-hEVs) in the repair of diabetic wounds.