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VicR is the essential response regulator related to the synthesis of exopolysaccharide (EPS) - one of the main cariogenic factors of S. mutans . An antisense vicR RNA (AS vicR ) could bind to vicR mRNA, hindering the transcription and translation of the vicR gene. We had constructed a recombinant plasmid containing the AS vicR sequence (plasmid-AS vicR ) and proved that it could reduce EPS synthesis, biofilm formation, and cariogenicity. However, the recombinant plasmids are supposed to be protected from enzymatic degradation and possess higher transformation efficiency. The principal objective of the present research was to construct an appropriate vector that can carry and protect the plasmid-AS vicR and investigate the effects of the carried plasmids on the cariogenicity of the S. mutans .

Antisense vicR-Loaded Dendritic Mesoporous Silica Nanoparticles Regulate the Biofilm Organization and Cariogenicity of Streptococcus mutans