Open AccessThermosensitive Tri-Block Polymer Nanoparticle-Hydrogel Composites as Payloads of Natamycin for Antifungal Therapy Against Fusarium Solani
Author(s) -
Xiao-Yuan Sha,
Leung Chan,
Xiaoyi Fan,
Penghao Guo,
Tianfeng Chen,
Lian Liu,
Jingxiang Zhong
Publication year - 2022
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s332127
Subject(s) - plga , fungal keratitis , peg ratio , cornea , nat , penetration (warfare) , chemistry , materials science , corneal inflammation , nuclear chemistry , nanoparticle , medicine , nanotechnology , ophthalmology , computer network , finance , operations research , computer science , engineering , economics
Fusarium Solani is the principal pathogen associated with fungal keratitis. As a sensitive drug to F. Solani , natamycin (NAT) was limited by the poor penetration and low bioavailability in clinical application. The aim of this study was to develop a new type of tri-block polymer nanoparticle-gel complex (Gel@PLGA-PEI-PEG@NAT) for delivering NAT and evaluate its physicochemical properties, antifungal activity, safety, penetrability, adhesion, and efficacy in treating fungal keratitis.