Open AccessProstate-Specific Membrane Antigen and Esterase Dual Responsive Camptothecin–Oligopeptide Self-Assembled Nanoparticles for Efficient Anticancer Drug Delivery
Author(s) -
Bing Xu,
Mengmeng Yan,
Fei Zhou,
Desheng Cai,
Wenbo Guo,
Xiaohui Jia,
Runping Liu,
Tao Ma,
Tong Li,
Feng Gao,
Penglong Wang,
Haimin Lei
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s331060
Subject(s) - camptothecin , drug delivery , chemistry , in vivo , cytotoxicity , glutamate carboxypeptidase ii , lncap , biochemistry , pharmacology , biophysics , cancer cell , in vitro , prostate cancer , biology , cancer , microbiology and biotechnology , organic chemistry , genetics
The clinical utility of camptothecin (CPT) is restricted by poor aqueous solubility, high lipophilicity, active lactone ring instability, and off-targeted toxicities. We report here a prostate-specific membrane antigen (PSMA) and esterase dual responsive self-assembled nanoparticles (CPT-WT-H NPs) for highly efficient CPT delivery and effective cancer therapy.