Open AccessOne Pot Synthesis of PEGylated Bimetallic Gold–Silver Nanoparticles for Imaging and Radiosensitization of Oral Cancers
Author(s) -
Shameer Ahmed,
Gunjan Baijal,
R. Somashekar,
Subramania Iyer,
Vijayashree Nayak
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s329762
Subject(s) - small angle x ray scattering , nanoparticle , materials science , dynamic light scattering , chemistry , nuclear chemistry , chemical engineering , nanotechnology , scattering , physics , engineering , optics
Radiotherapy is an important treatment modality for many types of head and neck squamous cell carcinomas. Nanomaterials comprised of high atomic number (Z) elements are novel radiosensitizers enhance radiation injury by production of free radicals and subsequent DNA damage. Gold nanoparticles are upcoming as promising radiosensitizers due to their high (Z) biocompatibility, and ease for surface engineering. Bimetallic nanoparticles have shown enhanced anticancer activity compared to monometallic nanoparticles.