Open AccessEnhancing of Nanocatalyst-Driven Chemodynaminc Therapy for Endometrial Cancer Cells Through Inhibition of PINK1/Parkin-Mediated Mitophagy
Author(s) -
Xiaodi Gong,
Xin Pu,
Jing Wang,
Linlin Yang,
Yanmei Cui,
Lijuan Li,
Xiaojiang Sun,
Jichang Liu,
Jing Bai,
Yudong Wang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s329341
Subject(s) - mitophagy , parkin , reactive oxygen species , pink1 , chemistry , glutathione , apoptosis , autophagy , microbiology and biotechnology , cancer cell , oxidative stress , cancer research , biochemistry , biology , cancer , medicine , enzyme , genetics , disease , parkinson's disease , pathology
Iron-based nanomaterials have recently been developed as excellent and potent Fenton reagents to reactive oxygen species (ROS) during chemodynamic therapy (CDT). The performance of the materials, however, can be impaired by the intrinsic antioxidant defense mechanism in organisms, such as autophagy.