Open AccessElemene Nanoemulsion Inhibits Metastasis of Breast Cancer by ROS Scavenging
Author(s) -
Bo Han,
Tao Wang,
Zhigang Xue,
Tao Wen,
Ling Lu,
Jie Meng,
Jian Liu,
Sizhu Wu,
Jian-chun Yu,
Haiyan Xu
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s327094
Subject(s) - elemene , cancer research , metastasis , breast cancer , triple negative breast cancer , cancer , curcumin , cytotoxicity , angiogenesis , in vitro , medicine , pharmacology , chemistry , pathology , apoptosis , biochemistry
Elemene (C 15 H 24 ) is a sesquiterpene compound extracted from the rhizome of Curcuma herbs. In the past decades, the anti-tumor activity of elemene has been observed in vitro and in some clinical practices. However, pharmacological mechanisms of elemene are not demonstrated adequately, which may lead to improper clinical applications. This study aimed to investigate the anti-tumor effect of elemene nanoemulsion in the mouse model of triple-negative breast cancer (TNBC) and reveal the underlying mechanisms.