Open AccessiRGD Peptide-Mediated Liposomal Nanoparticles with Photoacoustic/Ultrasound Dual-Modality Imaging for Precision Theranostics Against Hepatocellular Carcinoma
Author(s) -
Huipu Li,
Shasha Shi,
Meng Wu,
Wei Shen,
Jianli Ren,
Zhechuan Mei,
Haitao Ran,
Zhigang Wang,
Yuan Tian,
Jian Gao,
Hongyun Zhao
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s325891
Subject(s) - in vivo , indocyanine green , flow cytometry , in vitro , hepatocellular carcinoma , ultrasound , cancer research , chemistry , molecular imaging , biomedical engineering , medicine , pathology , radiology , biochemistry , immunology , biology , microbiology and biotechnology
Prepare a multifunctional ultrasound molecular probe, cell-penetrating peptide-modified 10-hydroxycamptothecin-loaded phase-transformation lipid nanoparticles (iRGD-ICG-10-HCPT-PFP-NPs), and to combine iRGD-ICG-10-HCPT-PFP -NPs with low-intensity focused ultrasound (LIFU) for precision theranostics against hepatocellular carcinoma (HCC).