Open AccessRadiolabeling and Preliminary Evaluation of 99mTc-Labeled DNA Cube Nanoparticles as Potential Tracers for SPECT Imaging
Author(s) -
Xiaoyan Duan,
Yiri Du,
Chunmei Wang,
Zhenfeng Zhao,
Chao Li,
Jianbo Li
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s325791
Subject(s) - biodistribution , chemistry , spect imaging , radiochemistry , biophysics , nuclear medicine , in vitro , biochemistry , medicine , biology
DNA nanostructures, with the advantages of structural designability and spatial addressability, have shown a great potential in the field of drug delivery and bio-medicine. Herein, we aimed to prepare technetium-99m radiolabeled DNA cube nanoparticles ( 99m Tc-DCN) and expect to build a DCN-based drug carrier and nuclear medicine imaging platform.