Open AccessFormulation, Optimization, and Evaluation of Oregano Oil Nanoemulsions for the Treatment of Infections Due to Oral Microbiota
Author(s) -
Khaled M. Hosny,
Hani Z. Asfour,
Waleed Y. Rizg,
Nabil A. Alhakamy,
Amal M. Sindi,
Hala M. Alkhalidi,
Walaa A. Abualsunun,
Rana B. Bakhaidar,
Alshaimaa M. Almehmady,
Sara Akeel,
S. Ali,
Adel F. Alghaith,
Sultan Alshehri,
Rasha A. Khallaf
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s325625
Subject(s) - box–behnken design , pulmonary surfactant , antifungal , solubility , chromatography , bioavailability , materials science , chemistry , pharmacology , response surface methodology , microbiology and biotechnology , medicine , biology , organic chemistry , biochemistry
Natural oil-based nanoemulsions (NEs) have been widely investigated in many diseases that affect the oral cavity. NEs are delivery systems that enhance the solubility of lipid therapeutics and improve their delivery to target sites; they are known as self-nanoemulsifying drug delivery systems (SNEDDSs). The current investigation's aim was to produce an oregano essential oil-based nanoemulsion (OEO-SNEDD) that would have antibacterial and antifungal effects against oral microbiota and improve oral health.