Open AccessHeptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel
Author(s) -
Athira Raveendran,
Suchithra Poilil Surendran,
Jinhui Ser,
Khurshed Alam,
Hoonsung Cho,
Yong Yeon Jeong
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s325322
Subject(s) - paclitaxel , in vivo , drug delivery , cytotoxicity , pharmacology , medicine , cancer research , cancer cell , in vitro , chemotherapy , cancer , chemistry , biology , biochemistry , microbiology and biotechnology , organic chemistry
Paclitaxel (PTX) is a conventional chemotherapeutic drug that effectively treats various cancers. The cellular uptake and therapeutic potential of PTX are limited by its slow penetration and low solubility in water. The development of cancer chemotherapy methods is currently facing considerable challenges with respect to the delivery of the drugs, particularly in targeting the tumor site without exerting detrimental effects on the healthy surrounding cells. One possibility for improving the therapeutic potential is through the development of tumor-targeted delivery methods.