Open AccessDesign and Preparation of “corn-like” SPIONs@DFK-SBP-M13 Assembly for Improvement of Effective Internalization
Author(s) -
Na Zhang,
Hui Wu,
Ying-Zhi Liang,
Jianming Ye,
Huan Zhang,
Yuqing Miao,
Yongsheng Luo,
Hai Fan,
Tianli Yue
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s325282
Subject(s) - internalization , chemistry , biophysics , recombinant dna , microbiology and biotechnology , nanocarriers , peptide , biochemistry , drug delivery , nanotechnology , materials science , cell , biology , gene
Superparamagnetic iron oxide nanoparticles (SPIONs) have exhibited preeminent diagnosis and treatment performances, but their low internalization severely limits predesigned functions. The low cell internalization is now an urgent bottleneck problem for almost all nanomaterials. To achieve more internalization of SPIONS, recombinant M13 phage was designed for targeted delivery and smart release.