Open AccessPenetration Enhancing of an Erythrocyte-Mimicking Nanoplatform via Papaverine for Radiosensitization
Author(s) -
Jinrui Zhang,
Huaicheng Wang,
Weilong Suo,
Zhizhou Li,
Chunxu Yang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s324314
Subject(s) - radiosensitizer , in vivo , pharmacology , papaverine , medicine , cancer cell , cancer research , angiogenesis , tumor hypoxia , vasodilation , radiation therapy , tumor microenvironment , biomedical engineering , materials science , cancer , tumor cells , biology , microbiology and biotechnology
Radiotherapy (RT) is recommended as an extensive therapeutic regimen for cancer patients; however, cancer radio-resistance results from reduced oxygen levels (hypoxia) in the tumor microenvironment. Herein, we report a therapeutic strategy that greatly enhances the treatment effects of RT.